Diseases
At The Liver Centre South Africa, we care for patients with a wide range of liver conditions, from early liver inflammation to advanced cirrhosis and liver cancer.
Fatty Liver Disease (NAFLD / NASH)
This happens when too much fat builds up in the liver.
-
Non-Alcoholic Fatty Liver Disease (NAFLD): Common in people with diabetes, obesity, or high cholesterol.
-
Non-Alcoholic Steatohepatitis (NASH): A more serious form that can cause scarring and progress to cirrhosis.
Healthy diet, weight control, and medical management are key treatments.
Alcohol-Related Liver Disease
Regular or heavy drinking can cause inflammation, scarring, and eventually liver failure.
Stopping alcohol completely is essential to allow the liver to heal.
We work closely with addiction specialists and hepatologists to support recovery and improve liver health.
Viral Hepatitis (Hepatitis B and C)
These are viral infections that cause inflammation of the liver.
-
Hepatitis B can be chronic and may lead to cirrhosis or liver cancer.
-
Hepatitis C can now be cured with modern antiviral medicines.
Vaccines are available for Hepatitis B to prevent infection.
Cirrhosis (Liver Scarring)
Cirrhosis is the end result of long-term liver damage from any cause - alcohol, hepatitis, or fatty liver.
Scar tissue replaces healthy liver tissue, affecting how the liver works.
Treatment focuses on controlling complications and preventing further damage. In severe cases, liver transplantation may be needed.
Liver Cancer (Hepatocellular Carcinoma – HCC)
HCC usually develops in people with cirrhosis or chronic hepatitis.
We use advanced imaging, interventional radiology (TACE/TARE), surgery, or transplantation to manage liver cancer depending on its stage and patient condition.
Early detection greatly improves outcomes.
Bile Duct Cancers (Cholangiocarcinoma)
These rare cancers affect the ducts that carry bile from the liver.
Symptoms include jaundice (yellow eyes or skin), itching, and dark urine.
Treatment often includes surgery, interventional radiology (for drainage or stenting), and chemotherapy.
Autoimmune Liver Diseases
In these conditions, the body’s immune system mistakenly attacks the liver.
-
Autoimmune Hepatitis (AIH) – causes inflammation.
-
Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC) – affect the bile ducts.
Treatment often includes immune-suppressing medication and close monitoring by a hepatologist.
Genetic and Metabolic Liver Disorders
Some liver diseases are inherited and may present in childhood or adulthood.
Examples include:
-
Hemochromatosis: too much iron stored in the body.
-
Wilson’s Disease: copper builds up in the liver and brain.
-
Alpha-1 Antitrypsin Deficiency: can cause liver and lung disease.
Early diagnosis and targeted treatment help prevent complications.
Portal Hypertension and Varices
When the liver becomes scarred, blood cannot flow through it easily.
This increases pressure in the portal vein system and can cause varices (enlarged veins) that may bleed.
Treatment includes medication, endoscopic therapy, or interventional procedures such as TIPS to relieve pressure.
Biliary Obstruction and Gallstones
Gallstones or strictures (narrowed bile ducts) can block the flow of bile, causing jaundice and infection.
These are managed with endoscopic (ERCP) or interventional radiology procedures to drain or open the ducts.
Acute Liver Failure
A sudden and severe loss of liver function, often due to toxins, infections, or medication reactions.
Patients require urgent care in a specialist unit, and in some cases, a liver transplant may be life-saving.
Post-Transplant Complications
After liver transplantation, patients may experience bile duct narrowing, vascular blockages, or rejection.
Our team provides long-term follow-up and interventional radiology support to maintain healthy liver function.